Publications

Publications of the Bionanomechanics Group

 

  • Cano Á, Yubero ML, Millá C, Puerto-Belda V, Ruz JJ, Kosaka PM, Calleja M, Malumbres M, Tamayo J (2024). Rapid mechanical phenotyping of breast cancer cells based on stochastic intracellular fluctuations. iScience. 27(11):110960. [PMID: 39493877]
  • Sentre-Arribas E, Aparicio-Millán A, Lemaître A, Favero I, Tamayo J, Calleja M, Gil-Santos E (2024). Simultaneous Optical and Mechanical Sensing Based on Optomechanical Resonators. ACS Sens. 9(1):371-378 [PMID: 38156765]
  • High Dynamic Range Nanowire Resonators, J. Molina, J. E. Escobar, D. Ramos, E. Gil-Santos, J. J. Ruz, J. Tamayo, Á. San Paulo, M. Calleja, Nano Letters 21, 6617 (2021) IF: 11,189. Citations: 3
  • Optomechanical detection of vibration modes of a single bacterium., E. Gil-Santos, J.J Ruz, O.Malvar, I. Favero, A. Lemaître, P.M Kosaka, S. García-López, M. Calleja, J.Tamayo. Nature Nanotechnology 15, 469 (2020). (Related patent). IF: 39,213. Citations: 47
  • Optical transduction for vertical nanowire resonators., J. Molina, D. Ramos, E. Gil-Santos, J.E- Escobar, J.J. Ruz, J. Tamayo, A. San Paulo, M. Calleja. Nano Letters 20, 2359 (2020). IF: 11,189. Citations: 5
  • Effects of energy metabolism on the mechanical properties of breast cancer cells, M. L. Yubero, P. M. Kosaka, Á. San Paulo, M. Malumbres, M. Calleja. J. Tamayo, Communications Biology 3, 590 (2020). IF: 5,49. Citations: 10
  • Mechano-Optical Analysis of Single Cells with Transparent Microcapillary Resonators, A. Martín-Pérez, D. Ramos, E. Gil-Santos, S. García-López, M.L. Yubero, P. M. Kosaka, Á. San Paulo, J. Tamayo, M. Calleja, ACS Sensors 4, 3325 (2019). IF: 7,12. Citations: 11
  • Nanomechanical Plasmon Spectroscopy of Single Gold Nanoparticles, D. Ramos, O. Malvar, Z.J. Davis, J. Tamayo, M. Calleja, Nano Letters 18, 7165, (2018). IF: 12,279. Citations:16
  • Mass and stiffness spectrometry of nanoparticles and whole intact bacteria by multimode nanomechanical resonators. Malvar, J. J. Ruz, P. M. Kosaka, C. M. Domínguez, E. Gil-Santos, M. Calleja, J. Tamayo, Nature Communications, 7, 13452 (2016). IF: 12,756. Citations: 83
  • Effect of actin organization on the stiffness of living breast cancer cells revealed by peak-force modulation atomic force microscopy. Calzado-Martín, M. Encinar, J. Tamayo, M. Calleja, A. San Paulo. ACS Nano 10, 3365-3374 (2016). IF: 14,562. Citations:179
  • Detection of cancer biomarkers in serum using a hybrid mechanical and optoplasmonic nanosensor, P.M.  Kosaka, V. Pini, J.J. Ruz, R. A. da Silva, M. Ujue-González, D. Ramos, M. Calleja, J. Tamayo, Nature Nanotechnology, 9, 1047 (2014). IF: 33.265 (Licensed related patent). Citations: 237
  • Biosensors based on nanomechanical systems, J. Tamayo, P. Kosaka, Álvaro San Paulo, J. J. Ruz, M. Calleja, Chemical Society Reviews 42 (3), 1287-1311 (2013), artículo de revisión por invitación. IF: 28.760. Citations: 381
  • Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers, C. M. Domínguez, D.l Ramos, J. I. Mendieta-Moreno, J. L. G. Fierro, J. Mendieta, J. Tamayo, M. Calleja, Scientific Reports 7, 536 (2017). IF: 4,61. Citations: 27
  • Physics of Nanomechanical Spectrometry of Viruses, J. J. Ruz, J. Tamayo, V. Pini, P. M. Kosaka, M. Calleja, Scientific Reports 4, 6051 (2014). IF: 5,78. Citations: 39

Thesis

  • Alberto Martín–Pérez, Resonadores Microcapilares Transparentes para la Caracterización Multiparamétrica de Células, 23/07/2021. Cum Laude.
  • Sergio García, Desarrollo de biosensores nanomecánicos y optoplmasónicos para la detección ultrasensible de proteínas (Física de la materia condensada, nanociencia y biofísica – UAM). 01/04/2022. Cum Laude.

Publications of Cell Division Cycle Group

  1. Malumbres M, Villarroya-Beltri C. (2024) Mosaic variegated aneuploidy in development, ageing and cancer. Nat Rev Genet. 2024 Aug 21. Online ahead of print [PMID: 39169218] Review
  2. Mayer IM, Doma E, Klampfl T, Prchal-Murphy M, Kollmann S, Schirripa A, Scheiblecker L, Zojer M, Kunowska N, Gebrail L, Shaw LE, Mann U, Farr A, Grausenburger R, Heller G, Zebedin-Brandl E, Farlik M, Malumbres M, Sexl V, Kollmann K. (2024) Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells. Blood. 144(2):156-170. [PMID: 38684032]
  3. Meattini I, Becherini C, Caini S, Coles CE, Cortes J, Curigliano G, de Azambuja E, Isacke CM, Harbeck N, Kaidar-Person O, Marangoni E, Offersen BV, Rugo HS, Salvestrini V, Visani L, Morandi A, Lambertini M, Poortmans P, Livi L, Consensus Panellist Group (incl. Malumbres M). (2024) International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations. Lancet Oncol. 25(2):e73-e83. [PMID: 38301705]
  4. Sanz-Flores, M., Ruiz-Torres M, Aguirre-Portolés C, El Bakkali A, Salvador-Barberó B, Ortega S, Megias D, Villarroya-Beltri C, Gerlich D, Álvarez-Fernández M, Malumbres M. (2024) PP2A-B55 phosphatase counteracts Ki67-dependent chromosome individualization during mitosis. Cell Reports. 43(7)114494. [PMID: 39003739]
  5. Vara-Ciruelos D, Malumbres M. (2024) Cross Talk Between Metabolism and the Cell Division Cycle. Methods Mol Biol. 2740:141-154. [PMID: 38393474]
  6. Hermida, D., Mortuza, G.B., Pedersen, A.K., Pozdnyakova, I., Nguyen, T.T.T.N., Maroto, M., Williamson, M., Ebersole, T., Cazzamali, G., Rand, K., Olsen, J.V., Malumbres, M. and Montoya, G. (2020) Molecular basis of the mechanisms controlling MASTL. Cell. Proteomics 19, 326-343. [PMID: 31852836]
  1. Sanz-Gómez, N., de Pedro, I., Ortigosa, B., Santamaría, D., Malumbres, M., de Carcer, G. and Gandarillas, A. (2020) Squamous differentiation requires G2/mitosis slippage to avoid apoptosis. Cell Death Differ., 27, 2451-2467. [PMID: 32080348]
  2. Salvador-Barbero, B., Álvarez-Fernández, M., Zapatero-Solana, E., El Bakkali, A., Menéndez, M.C., López-Casas, P.P., Di Domenico, T., Xie, T., VanArsdale, T., Shields, D.J., Hidalgo, M. and Malumbres, M. (2020) CDK4/6 inhibitors impair recovery from cytotoxic chemotherapy in pancreatic adenocarcinoma. Cancer Cell 37, 340-353. [PMID: 32109375]
  3. Álvarez-Fernández, M. and Malumbres, M. (2020) Mechanisms of sensitivity and resistance to CDK4/6 inhibitors. Cancer Cell 37, 514-529. [PMID: 32289274]
  4. Martínez-Alonso, D. and Malumbres, M. (2020) Mammalian cell cycle cyclins. Cell. Dev. Biol., 107, 28-35. [PMID: 32334991]
  5. Salazar-Roa, M., Trakala, M., Álvarez-Fernández, M., Valdés-Mora, F., Zhong, C., Muñoz, J., Yu, Y., Peters, T.J., Graña-Castro, O., Serrano, R., Zapatero-Solana, E., Abad, M., Bueno, M.J., Gómez de Cedrón, M., Fernández-Piqueras, J., Serrano, M., Blasco, M.A., Wang, DZ., Clark, S.J., Izpisúa-Belmonte, J.C., Ortega, S., Malumbres, M. (2020) Transient exposure to miR-203 enhances the differentiation capacity of established pluripotent stem cells. EMBO J, 39, e104324. bioRxiv 826446; doi: https://doi.org/10.1101/826446. [PMID: 32614092]
  6. Salazar-Roa, M., Martínez-Martínez, S., Graña-Castro, O., Álvarez-Fernández, M., Trakala, M., Redondo, J.M., Malumbres, M. (2020) miR-203 imposes an intrinsic barrier during cellular reprogramming by targeting NFATC2. bioRxiv. https://doi.org/10.1101/2020.06.02.131136.
  7. Yubero, M.L., Kosaka, P.M., San Paulo, A., Malumbres, M., Calleja, M., Tamayo, J. (2020) Effects of energy metabolism on the mechanical properties of breast cancer cells. Biol. 3, 590. [PMID: 33082491]
  8. Alfaro, E., López-Jiménez, P., González-Martínez, J., Malumbres, M., Suja, J.A., Gómez, R. (2021) PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis. EMBO Rep. 22, e51030. doi: 10.15252/embr.202051030. [PMID: 33615693]
  9. Galarreta, A., Valledor, P., Ubieto-Capella, P., Lafarga, V., Zarzuela, E., Muñoz, J., Malumbres, M., Lecona, E. and Fernandez-Capetillo, O. (2021). USP7 limits CDK1 activity throughout the cell cycle EMBO J 40, doi: 10.15252/embj.201899692. [PMID: 33856059]
  10. González-Martínez, J. and Malumbres, M. (2021) Expanding the Differentiation Potential of Already-Established Pluripotent Stem Cells. Methods Mol Biol. 2454, 95-107. doi: 10.1007/7651_2021_408. [PMID: 34128208]
  11. González-Martínez, J., Cwetsch, A.W., Martínez-Alonso, D., López-Sainz, L.R., Almagro, J., Megías, D., Boskovic, J., Gilabert-Juan, J., Graña-Castro, O., Pierani, A., Behrens, A., Ortega, S. Malumbres, M. (2021) Deficient Adaptation to Centrosome Duplication Defects in Neural Progenitors Causes Microcephaly and Subcortical Heterotopias. JCI Insights 6, e146364. doi: 10.1172/jci.insight.146364. [PMID: 34237032]
  12. González-Martínez J, Cwetsch AW, Gilabert-Juan J, Gómez J, Garaulet G, Schneider P, de Cárcer G, Mulero F, Caleiras E, Megías D, Porlan E, Malumbres M. (2022) Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division. Cell Death Differ. 29,1474-1485. doi: 10.1038/s41418-022-00937-w. [PMID: 35058575]
  13. Berenguer, I., López-Jiménez, P., Mena, I., Viera, A., Page, J., González-Martínez, J., Maestre, C., Malumbres, M., Suja, J.A., Gómez, R. (2022) Haspin participates in AURKB recruitment to centromeres and contributes to chromosome congression in male mouse meiosis. J Cell Sci. 135, jcs259546. doi: 10.1242/jcs.259546. [PMID: 35694956]
  14. Villarroya-Beltri C, Malumbres M. (2022) Mitotic Checkpoint Imbalances in Familial Cancer. Cancer Res 82, 3432-3434. doi: 10.1158/0008-5472.CAN-22-2400. [PMID: 36193651]
  15. Villarroya-Beltri C, Osorio A, Torres-Ruiz R, Gómez-Sánchez D, Trakala M, Sánchez-Belmonte A, Mercadillo F, Hurtado B, Pitarch B, Hernández-Núñez A, Gómez-Caturla A, Rueda D, Perea J, Rodríguez-Perales S*, Malumbres M*, Urioste M*. (2022) Biallelic germline mutations in MAD1L1 induce a syndrome of aneuploidy with high tumor susceptibility. Sci Adv. 8, eabq5914. doi: 10.1126/sciadv.abq5914. [PMID: 36322655] [*, co-corresponding]
  16. Hidalgo, M., Garcia-Carbonero, R., Lim, K.H., Messersmith, W.A., Garrido-Laguna, I., Borazanci, E., Lowy, A.M., Medina Rodriguez, L., Laheru, D., Salvador-Barbero, B., Malumbres, M., Shields, D.J., Grossman, J.E., Huang, X., Tammaro, M., Martini, J.F., Yu, Y., Kern, K., Macarulla, T. (2022) A Preclinical and Phase 1b Study of Palbociclib Plus Nab-Paclitaxel in Patients With Metastatic Adenocarcinoma of the Pancreas. Cancer Res Commun., 2, 1326–1333. https://doi.org/10.1158/2767-9764.CRC-22-0072.
  17. Mouron S, Bueno MJ, Lluch A, Manso L, Calvo I, Cortes J, Garcia-Saenz JA, Gil-Gil M, Martinez-Janez N, Apala JV, Caleiras E, Ximénez-Embún P, Muñoz J, Gonzalez-Cortijo L, Murillo R, Sánchez-Bayona R, Cejalvo JM, Gómez-López G, Fustero-Torre C, Sabroso-Lasa S, Malats N, Martinez M, Moreno A, Megias D, Malumbres M, Colomer R, Quintela-Fandino M. (2022) Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A. Nat Commun. 13, 7529. doi: 10.1038/s41467-022-35065-z. [PMID: 36477027]
  18. Frontiñán-Rubio J, Llanos-González E, García-Carpintero S, Peinado JR, Ballesteros-Yáñez I, Rayo MV, de la Fuente J, Pérez-García VM, Perez-Romasanta LA, Malumbres M, Alcaín FJ, Durán-Prado M. (2023) CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation. Cell Oncol 46, 65-77. doi: 10.1007/s13402-022-00734-0. [PMID: 36319818]
  19. Villarroya-Beltri C, Martins AFB, García A, Giménez D, Zarzuela E, Novo M, Del Álamo C, González-Martínez J, Bonel-Pérez GC, Díaz I, Guillamot M, Chiesa M, Losada A, Graña-Castro O, Rovira M, Muñoz J, Salazar-Roa M, Malumbres M. (2023) Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells. EMBO J. 42, e111251. doi: 10.15252/embj.2022111251. [PMID: 36326833]
  20. Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martínez-Alonso D, González-Martínez J, Santiveri C, Campos-Olivas R, Ximénez-Embún P, Muñoz J, Álvarez-Fernández M, Malumbres M. (2023) The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. EMBO J. 42, e110833. doi: 10.15252/embj.2022110833. [PMID: 36354735]
  21. Dhital B, Santasusagna S, Kirthika P, Xu M, Li P, Carceles-Cordon M, Soni RK, Li Z, Hendrickson RC, Schiewer MJ, Kelly WK, Sternberg CN, Luo J, Lujambio A, Cordon-Cardo C, Alvarez-Fernandez M, Malumbres M, Huang H, Ertel A, Domingo-Domenech J, Rodriguez-Bravo V. (2023) Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer. Cell Rep Med. 4, 100937. doi: 10.1016/j.xcrm.2023.100937. [PMID: 36787737]
  22. Mouron S, Bueno MJ, Muñoz M, Torres R, Rodríguez S, Apala JV, Silva J, Sánchez-Bayona R, Manso L, Guerra J, Rodriguez-Lajusticia L, Malon D, Malumbres M, Quintela-Fandino M. (2023) p27Kip1 V109G as a biomarker for CDK4/6 inhibitors indication in hormone receptor-positive breast cancer. JNCI Cancer Spectr. Feb 20:pkad014. doi: 10.1093/jncics/pkad014. [PMID: 36806942]
  23. Olivera-Salguero R, Seguí E, Cejalvo JM, Oliveira M, Tolosa P, Vidal M, Malumbres M, Gavilá J, Saura C, Pernas S, López R, Margelí M, Balmaña J, Muñoz M, Blancas I, Boni V, Ciruelos E, Galve E, Perelló A, Sánchez-Bayona R, de la Cruz S, de la Hoya M, Galván P, Sanfeliu E, Gonzalez-Farre B, Sirenko V, Blanch-Torras A, Canes J, Masanas H, Olmos R, Forns M, Prat A, Casas A*, Pascual T* (2023) HOPE (SOLTI-1903) Breast Cancer Study: Real-world, patient-centric, clinical practice study to assess the impact of genomic data on next treatment decision-choice in patients with locally advanced or metastatic breast cancer. Front Oncol 13:1151496. [PMID: 37188177]
  24. Sayago C, Sánchez-Wandelmer J, García F, Hurtado B, Lafarga V, Prieto P, Zarzuela E, Ximénez-Embún P, Ortega S, Megías D, Fernández-Capetillo O, Malumbres M, Munoz J. (2023) Decoding protein methylation function with thermal stability analysis. Nat Commun. 14, 3016. [PMID: 37230995] doi: 10.1038/s41467-023-38863-1.
  1. Submitted for publication
  1. Sayago, C., Sanchez, J., García, F., Hurtado,, B., Lafarga, V., Prieto, P., Zarzuela, E., Ximenez-Embun, P., Ortega, S., Megias, D., Fernandez-Capetillo, O., Malumbres, M., Muñoz, J. Decoding protein methylation function with thermal stability analysis. Submitted to Commun.
  2. Martínez-Alonso D., López-Sainz, L.R., Villarroya-Beltri, C., Wakahashi, S., González-Martínez J., Nogueira, E., Megias, D., Sánchez, J., Geley, S., Muñoz, J., Ortega, S., Ferguson, F.N., Gray, N.S., Shields, D.J., Lujambio, A., de Cárcer, G., Malumbres, M. CDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma. Submitted to Cancer Cell.
  3. Baldrighi, M., Doreth, C., Chenoweth, H., Warner, E., Thome, S., Knapton, A., Harrison, J., Clarke, M., Latz, E., de Carcer, G., Malumbres, M., Ryffel, B., Bryant, C., Mallat, Z., Li, X. PLK1 promotes NLRP3 inflammasome activation through reinforcing microtubule organizing center. Submitted for publication.
  4. Ha, J., Cho, Y.C., Ju, A., Jeong, D.G., Kim, B.R., Lee, S., Malumbres, M., Kim, J.H., Park, S.G., Park, B.C. and Cho, S. Cell division cycle 14B regulates epithelial-mesenchymal transition transcription factor Snail1. Submitted for publication.

Thesis defended

  • Date: 10/12/2021
    Author: Martínez-Alonso, Diego
    Tittle:     Characterization of CDK14-18 as therapeutic targets in hepatocellular carcinoma M. Director: Malumbres & G. de Cárcer
    Univ. Autónoma de Madrid       Fac. Medicina

  • Date: 13/06/2022
    Author: González-Martínez, José
    Tittle: Physiological relevance of cell division regulators in mammalian neural development
    Director: M. Malumbres
    Univ. Complutense de Madrid   Fac. Ciencias Químicas

Proyecto sinérgico de I+D de la convocatoria 2020 de la Comunidad de Madrid con referencia Y2020/BIO-6519, acrónimo "scCANCER-CM"

  • mmm@cnio.es

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